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The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability
We found no evidence that rs1800734 or other MLH1 SNPs were associated with the risk of MSI EC. We found the rs1800734 risk allele had no effect on MLH1 methylation or expression in ECs. We propose that MLH1 hypermethylation occurs by different mechanisms in CRC and EC.
Holly Russell
,
Kasia Kedzierska
,
Daniel D Buchanan
,
Rachael Thomas
,
Emma Tham
,
Miriam Mints
,
Anne Keränen
,
Graham G. Giles
,
Melissa C. Southey
,
Roger L. Milne
,
Ian Tomlinson
,
David Church
,
Amanda B. Spurdle
,
Tracy A. O’Mara
,
Annabelle Lewis
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