heart development

Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development
Loss of function of cardiac TFs Gata5, Tbx5a, and Hand2 affected the cardiac regulatory networks and caused global changes in chromatin accessibility profile, indicating their role in heart development. Among regions with differential chromatin accessibility in mutants were highly conserved noncoding elements that represent putative enhancers driving heart development.
Michal Pawlak, Kasia Kedzierska, Maciej Migdal, Karim Abu Nahia, Jordan A Ramilowski, Lukasz Bugajski, Kosuke Hashimoto, Aleksandra Marconi, Katarzyna Piwocka, Piero Carninci, Cecilia L. Winata
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Dynamics of cardiomyocyte transcriptome and chromatin landscape demarcates key events of heart development