cancer

My PhD: Chromatin organisation in the cancer of the uterus
I seek to understand the chromatin organisation in endometrial cancer (cancer of the uterus). My goal is to link the genetic (changes in DNA sequence) perturbations to epigenetic (changes other than DNA sequence) modifications. For one, I want to understand how mutations in the SWI/Snf complex influence chromatin structure in uterine cancer and how they link to disease progression.
My PhD: Chromatin organisation in the cancer of the uterus
The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability
We found no evidence that rs1800734 or other MLH1 SNPs were associated with the risk of MSI EC. We found the rs1800734 risk allele had no effect on MLH1 methylation or expression in ECs. We propose that MLH1 hypermethylation occurs by different mechanisms in CRC and EC.
Holly Russell, Kasia Kedzierska, Daniel D Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara, Annabelle Lewis
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The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability
Genomic analysis of DNA repair genes and androgen signaling in prostate cancer
Androgen signaling regulates a subset of DNA repair genes that are largely specific to the respective model system and disease state
Kasey Jividen, Kasia Kedzierska, Chun-Song Yang, Karol Szlachta, Aakrosh Ratan, Bryce M Paschal
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Genomic analysis of DNA repair genes and androgen signaling in prostate cancer