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We found no evidence that rs1800734 or other MLH1 SNPs were associated with the risk of MSI EC. We found the rs1800734 risk allele had no effect on MLH1 methylation or expression in ECs. We propose that MLH1 hypermethylation occurs by different mechanisms in CRC and EC.

Loss of function of cardiac TFs Gata5, Tbx5a, and Hand2 affected the cardiac regulatory networks and caused global changes in chromatin accessibility profile, indicating their role in heart development. Among regions with differential chromatin accessibility in mutants were highly conserved noncoding elements that represent putative enhancers driving heart development.

Androgen signaling regulates a subset of DNA repair genes that are largely specific to the respective model system and disease state

SONiCS performs dense forward simulations of the PCR of Short Tandem Repeats from capture experiments, calculates the likelihood of generating the provided read support (reads per allele) out of the final PCR pool and determines the most probable genotype based on the log likelihood distributions from all such simulations.